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Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair.
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Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair.

Muscle Nerve. 2020 Jun 04;:

Authors: Rink S, Chatziparaskeva C, Elles L, Pavlov S, Nohroudi K, Bendella H, Sarikcioglu L, Manthou M, Dunlop SA, Gordon T, Angelov DN

Abstract
INTRODUCTION: After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono-innervated neuro-muscular junctions (NMJ). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ-mono-innervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor-2 (FGF2) and brain derived neurotrophic factor (BDNF) in denervated vibrissal muscles.
METHODS: We used normally-sighted rats (Wistar), in which NMJ-poly-innervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti-BDNF and FGF2 at different postoperative periods after facial nerve injury.
RESULTS: Rats receiving anti-BDNF+FGF2 showed low NMJ-poly-innervation and best recovery of whisking amplitude.
DISCUSSION: Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them. This article is protected by copyright. All rights reserved.

PMID: 32497302 [PubMed - as supplied by publisher]